Postdocs Gene Therapy for Hematological Disorders - Amsterdam, Nederland - Sanquin

Beschrijving

Sanquin Blood Supply Foundation uniquely combines medical, diagnostic, blood bank and research activities. With 2,000 committed colleagues and 345,000 blood donors, we aim to provide a better life for 300,000 patients each year.

The Division of Research and Lab Services of Sanquin is home to 250 researchers, including over 60 PhD students. Research at Sanquin is organized in four strategic themes: Anemia, Bleeding & Hemostasis, Immunity & Inflammation, and Immune Therapy. The joint mission of research at Sanquin is to invent novel methods and approaches using blood cells and blood products to prevent, diagnose, treat, or cure disease in donors and patients. Research activities cover the full spectrum of early inventions, development into novel products and services, donor studies, and clinical studies in patients.

Our research labs are equipped with state-of-the-art facilities, including flow cytometry and cell sorting, macromolecular mass spectrometry and proteomics, and imaging. Many of our scientists have academic affiliations with Dutch Universities and University Medical Centers. Sanquin is strategically located in Amsterdam, with a special tie to the AmsterdamUMC (Joint Landsteiner Laboratory). Within our research-team that focuses on bleeding and hemostasis we are now looking for 2 postdocs for our gene therapy program.

Gene therapy program Sanquin.

The gene therapy group within Sanquin focuses on further improvement of the quality of life of patients with hematological disorders. In our program we focus on AAV-mediated gene therapy for liver disorders. Within the context of Eurostars and Health Holland funded grants we employ capsid engineering to further improve the targeting efficacy and reduce the reactivity with pre-existing neutralizing antibodies of the current generation of gene therapy vectors. For this project we are looking for a postdoc with experience in AAV mediated gene therapy. In a separate line of research we aim to establish non-viral approaches for in vivo targeting of hematopoietic stem cells. We aim to develop novel technologies to selectively target mobilized and/or resident HSC with the overall goal of developing in vivo hematopoietic stem cell therapies for platelet, rare bleeding and potentially also other hematological disorders. For this program we are looking for a postdoc with experience in nanoparticle mediated gene delivery as well as genome engineering technologies.

Our expectations

We anticipate the newly recruited scientists to contribute with their unique expertise, complementing our existing research portfolio. This includes inflammation and complement research, genetic and cellular approaches to correct and cure hematological disorders. We are particularly interested in candidates who have experience with non-viral based gene delivery technologies and genome engineering. We will also will be able to prioritize candidates with expertise in synthetic biology in the context of vector development for gene therapy.

Our offer

We offer an international - academically oriented - research environment with state of-the-art equipment. We have excellent research facilities that are fully available for the research projects. We actively collaborate with academic groups within the Netherlands and Europe, have links to start-up as well as established biotech companies and an excellent network of clinical collaborators that allow us to bring innovations to the clinic. We perform research an fully open and transparent manner fully valueing the contribution and input of our researchers to the innovations we are developing in our team science based efforts.

A challenging translational project in a multi-disciplinary and enthusiastic (inter)national team;

Salary and conditions are conform CAO Sanquin;

8.33% end-of-year bonus; i.e. a thirteenth month in case of full-year employment;

Partial reimbursement of travel costs;

Pension plan with Pensioenfonds Zorg & Welzijn (PFZW);

At fulltime employment (36 hours) 201 hours of leave per annum.

Learn more about our terms of employment at

Applications

If you are interested in one of these positions, please apply by submitting your CV before the 3th of May. Please also provide a brief statement on your research interest and the contribution you expect to be able to make to our research program. More information can be obtained from the website ) or by sending an email to the Prof. dr. Jan Voorberg ). A pre-employment screening will be part of the onboarding procedure.

Acquisition is not appreciated. Sanquin does not accept unsolicited help from agencies for vacancies. CV's sent (in any form whatsoever) by placement agencies to any Sanquin employee without a valid written assignment by HR Sanquin will be considered property of Sanquin for which no compensation is owed in any way..