Research Technician - Utrecht, Nederland - Prinses Máxima Centrum

Prinses Máxima Centrum

Geverifieerd bedrijf

Utrecht, Nederland

2 weken geleden

Geplaatst door:

Daan Van den Berg

werver van beBee

Beschrijving

The Kemmeren group is looking for an enthusiastic, highly motivated research technician who excels in a stimulating, multi-disciplinary research environment and can play a central role in several research projects within the group.

Tasks and responsibilities

Profile

Our job offer

A full time position (36 hours a week) initially for one year, with the intention to extend after this initial period.

You will be working in a very stimulating and cross-disciplinary research environment, combining cutting-edge research with state-of-the-art molecular technologies.

Your gross monthly salary will depend on experience and background, starting in scale 45 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus.

The Princess Máxima Center operates according to the collective labor agreement 'cao algemene ziekenhuizen'.

About the Kemmeren group

The Kemmeren group exploits cancer omics data through a combination of bioinformatics and systems biology approaches to understand the mutational landscape of childhood cancers and its relationship to tumor biology for improved patient care.

Examples include driving bioinformatics research for precision oncology and diagnostics, improving structural variation detection and understanding, investigating mechanisms of genetic interactions and predicting tumor subtypes in childhood cancer.

We have developed a unique combination of expertise in bioinformatics, cancer omics and molecular-genetic interactions.

While our focus is on computational aspects, we collaborate with (pediatric) tumor biology groups, thus enabling a truly multidisciplinary approach.

Within the group, we currently have an opening for a research technician within the larger framework of unravelling genetic interactions in cancer as well as support other research projects within the group.

Research Project
Cancers arise and progress through the acquirement of combinations of mutations. Genetic interactions are specific combinations of mutations that have unpredictable phenotypic consequences.

Thorough understanding of genetic interactions, their underlying mechanisms and relation to pediatric cancer is crucial for deciphering cancer predisposition, onset and progression as well as for developing precision medicine approaches.

Two genetic interaction types are of particular importance for cancer. Detailed understanding of cooperative interactions will aid in elucidating general principles governing cancer onset and progression. Understanding mutually exclusive interactions is pivotal for developing more effective cancer drugs.

A detailed molecular understanding of cooperative and mutually exclusive alterations is vital for elucidating general principles underlying these types of genetic interactions in the context of pediatric cancers.

Using in vitro cell models (such as cell lines and patient-derived tumor organoids), we will further investigate several of the cooperative and mutually exclusive interactions found.

A variety of cell models and experimental procedures will be used, depending on the cancer type and particular genetic interaction(s) involved.

This will be performed in close collaboration with the Drost group (organoids and kidney tumors).

One example includes a mutually exclusive interaction found between DROSHA and TP53 in Wilms' tumors for which experimental validation in organoid cultures has already been initiated and which will be further explored in this project.

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